The Wretched follows four young experiments of a mad scientist called "amalgams" (creatures made of human, animal, and machine), who are sent out to kidnap humans for their master in a diseased and decaying region called Rhomheim. But while they're as playful as they are cruel to both humans and each other, they must confront new and difficult emotions that conflict against their brutal amalgam natures, and journey through self-discovery and vulnerability to unwillingly become what they hate most: Being human.